![]() It dictates whether the Purkinje neuron is quiescent or spontaneously firing in a continuous tonic, continuous burst, bimodal (tonic and quiescent), trimodal (tonic, burst, quiescent), or bimodal (burst and quiescent) repeat pattern. In vitro, the Na +/K + pump has been shown to control and set the intrinsic activity mode of Purkinje neurons (Forrest, 2008, 2014a Forrest et al., 2009, 2012). ![]() ![]() Thus, the pump is electrogenic, extruding one net charge per cycle to hyperpolarize the membrane potential. The Na +/K + pump uses the energy of one ATP molecule to exchange three intracellular Na + ions for two extracellular K + ions (Glitsch, 2001). Purkinje neurons are found in the cerebellum, responsible for motor control (Ito, 1984). In the intervening period it was serially rejected by reviewers and journals that were uncomfortable with this re-appraisal of Na +/K + pump function. thesis (Forrest, 2008), but has only been published relatively recently. This research was conducted in 2006–2007, and presented in a 2008 Ph.D. However, novel research upon cerebellar Purkinje neurons suggests that the Na +/K + pump may have a direct role in brain coding and computation (Forrest, 2008, 2014a, b Forrest et al., 2009, 2012). This is the long-held, entrenched viewpoint. So, the Na +/K + pump has a “housekeeping” role rather than a direct role in brain signaling. After an AP, the Na +/K + pump resets the arrangement of Na + and K + ions back to their original positions so that the neuron is then ready to relay another AP when it is called upon to do so (Glitsch, 2001). ![]() Brain neurons can transmit signals using a flow of Na + and K + ions, which produce an electrical spike called an action potential (AP) (Hodgkin and Huxley, 1952). ![]()
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